Roundup Herbicide 125 Times More Toxic

Roundup Herbicide 125 Times More Toxic Than Regulators Say:

 

Roundup Herbicide 125 Times More Toxic Than Regulators Say

Roundup Herbicide 125 Times More Toxic Than Regulators Say

A highly concerning new study published in the journal Biomedical Research International reveals that despite the still relatively benign reputation of agrochemicals such as Roundup herbicide, many chemical formulations upon which the modern agricultural system depend are far more toxic than present regulatory tests performed on them reveal. Roundup herbicide, for instance, was found to be 125 times more toxic than its active ingredient glyphosate studied in isolation.

Titled, “Major pesticides are more toxic to human cells than their declared active principles,” the study evaluated to what extent the active principle (AP) and the so-called ‘inert ingredients,’ i.e. adjuvants, in globally popular formulations account for the toxicity of 9 major pesticides: 3 herbicides, 3 insecticides, and 3 fungicides.

The Deceptive Semantics of Pesticide Formulations And Their Regulation

The paper describes how the agrochemical industry conceals the true toxicity of their chemical formulations by focusing on the health risks associated with only one so-called ‘active principle’ (AP) in their complex formulations, and sets the public up for mass poisoning through the determination of an ‘acceptable level of harm’ via the calculation of the so-called ‘acceptable daily intake (ADI)’ based on the toxicological risk profile of only a single ingredient:

“Pesticides are used throughout the world as mixtures called formulations. They contain adjuvants, which are often kept confidential and are called inerts by the manufacturing companies, plus a declared active principle (AP), which is the only one tested in the longest toxicological regulatory tests performed on mammals. This allows the calculation of the acceptable daily intake (ADI)—the level of exposure that is claimed to be safe for humans over the long term—and justifies the presence of residues of these pesticides at “admissible” levels in the environment and organisms. Only the AP and one metabolite are used as markers, but this does not exclude the presence of adjuvants, which are cell penetrants.”

The problem of underestimated toxicological risk is so severe that the researchers describe previous research which found unexpected toxicity in so-called ‘inert’ adjuvants that were up to 10,000 times more toxic than the so-called active principle glyphosate itself, revealing them to be a greater source for secondary side effects than the main ingredient itself. They also note that this ‘synergistic toxicity’ may explain the results of previous long-term animal research where glyphosate-based formulations showed toxicity in the parts-per-trillion range (.1 part per billion) that could not be explained by glyphosate alone.

Dr. Kelly Brogan, MD, commented on this phenomena in connection with the study recently on her blog: “Similar to the non-placebo-controlled trials on vaccines, adjuvants and preservatives are considered innocent bystanders in the consideration of risk profile.” According to Dr. Brogan, an understanding of “Toxicant synergy has exploded the simplistic notion of “the dose makes the poison.””

The Test Method and Results

In order to ascertain the toxicity of various chemical formulations and their ingredients, the researchers used embryonic (HEK293), placental (JEG3), and hepatic (HepG2) human cell lines, “because they are well characterized and validated as useful models to test toxicities of pesticides, corresponding to what is observed on fresh tissue or primary cells.”  They noted, “these cells lines are even in some instances less sensitive than primary cells, and therefore do not overestimate cellular toxicity.”

The researchers describe the their method of determining toxicity:

We assayed their mitochondrial succinate dehydrogenase (SD) activity (MTT assay) after 24h pesticide exposure, which is one of the most accurate cytotoxicity assays for measuring the toxicity of pesticide adjuvants such as surfactants. Cytotoxicity was confirmed by the measurement of apoptosis and necrosis, respectively, by caspases 3/7 activation and adenylate kinase leakage after membrane alterations

The results of the study were clear. Except for one pesticide (Matin), “All formulations were cytotoxic and far more toxic than their APs [active principles].”

Key findings included:

  • On human cells, among the tested products, fungicides were the most toxic, being cytotoxic from doses 300–600 times lower than agricultural dilutions, followed by herbicides (except Matin) and then insecticides.
  • In all cell types, fungicides were the most toxic (mean LC50 12ppm).
  • The herbicide Roundup (LC50 63ppm) was next in toxicity to fungicides, twice as toxic as Starane, and more than 10 times as toxic as the 3 insecticides, which represent the less toxic group (mean LC50 720ppm).

Monsanto’s Linked to Serious Soil Damage

Monsanto’s Roundup Pesticide Linked to Serious Soil Damage:

Glyphosate

Glyphosate

Glyphosate, the key ingredient in Monsanto’s Roundup pesticide, is being linked to damaged soil and roots of treated plants, finds 15 years of study, according to a representative from the USDA. Fungal root disease has increased among farmers using the popular Roundup pesticide, particularly on the Monsanto genetically modified Roundup Ready seeds, according to Bob Kremer, a microbiologist with the U.S. Department of Agriculture’s Agricultural Research Service. GM corn and soybeans represent a majority of Roundup dependent crops grown in the U.S., and this “invisible” plight of changes in soil bacteria and increased presence of fungus could indicate larger problems ahead with Monsanto’s Roundup Ready and other GMO seeds. With so many farmers in the U.S. now dependent on glyphosate pesticides and genetically modified seeds, the implications of widespread soil fungus are tremendous as a resistant fungus could devastate farms. The presence of newly discovered glyphosate resistant “superweeds” are already taking a toll on farmers’ crops and machinery. The research also revealed that the controversial genetically altered crops are not showing signs of yielding more than conventional crops, despite that being one of the key selling points of genetically modified seed manufacturers including Monsanto. Nutrient deficiencies linked to the root disease problems are likely a limiting factor, Kremer says, and the fungal diseases could limit crop health and production even further in the future warranting significantly more research. Among the growing concerns over heavy use of glyphosate based pesticides are links to human and livestock health risks including cancer, fertility issues, birth defects, organ damage and neurological disorders.

Monsanto’s Roundup is causing DNA Damage

Monsanto’s Roundup Ultra Max, is causing both DNA and cellular damage to cells found in the mouth and throat:

Monsanto’s Roundup Ultra Max, is causing both DNA and cellular damage to cells found in the mouth and throat

Monsanto’s Roundup Ultra Max, is causing both DNA and cellular damage to cells found in the mouth and throat

There is a reason that masks are worn while applying herbicides and warning signs are erected upon recently sprayed land plots — herbicide exposure is known to cause serious health complications. New research has recently been released showing that glyphosate, the main active ingredient found in Monsanto’s Roundup Ultra Max, is causing both DNA and cellular damage to cells found in the mouth and throat. Seeing as the inhalation of herbicides and ingredients like glyphosate is very common, this research alone is enough to raise concern over the safety of such substances which are used on a major scale. The Institute of Science in Society reports:

…Monsanto’s formulated version of glyphosate called Roundup Ultra Max caused cellular damage and DNA damage including chromosomal abnormalities and ultimately killed the cells at higher concentrations. Importantly, DNA damage occurred at concentrations below those required to induce cell damage, suggesting that the DNA damage was caused directly by glyphosate instead of being an indirect result of cell toxicity.

The research comes shortly after Monsanto’s all-to-popular Roundup has been shown to be killing off human kidney cells – even at low doses. Scientists demonstrated in the research that Monsanto’s ‘biopesticide’ Bt, in addition to Roundup, cause direct toxicity to human cells. They found that at only 100 parts per million (ppm), the biopesticide led to cell death, while it only took 57.2ppm of Roundup to kill half of the cell population in their research. Turns out that the amount of Roundup shown to cause this damage is 200 times below agricultural use. Although harm caused by glyphosate and Roundup is thought to be experienced only by those spraying the herbicide, Roundup may actually causing harm to millions of people. Roundup is not only sprayed on the food we eat, but it is also used by countless households as a consumer herbicide product. Roundup is so prevalent that it has been found in 41 percent of the 140 groundwater samples tested from Catalonia Spain. Even more concerning, a recent German study found glyphosate in all urine samples tested in concentrations at 5 to 20-fold the limit established for drinking water. Despite the evidence stacking up against Monsanto, they continue to push their health-damaging products on the public through personal and commercial use.