Artificial Bone Marrow

Researchers Develop Artificial Bone Marrow:

 Hematopoietic Stem Cells

Hematopoietic Stem Cells

Blood cells such as erythrocytes or immune cells are continuously replaced by new supplied hematopoietic stem cells are found in a specialized bone marrow niche . Hematopoietic stem cells can be used for treatment of blood diseases such as leukemia. Patient affected cells are replaced by healthy blood stem cells from a donor eligible .

However, not all leukemia patients can be treated in this way, as the appropriate number of transplants is not enough. This problem could be solved by the reproduction of hematopoietic stem cells. These cells maintain their stem cell properties in their natural environment only , that is, in its bone marrow niche . Out of this niche market , properties are modified. Therefore, stem cell reproduction requires a similar stem cell niche in the bone marrow environment .

Stem cell niche, is a complex microscopic environment that has specific properties . The relevant areas are highly porous bone and spongelike . This not only accommodate dimensional environment of bone cells and hematopoietic stem cells, but also various other types of cells with which signal substances are exchanged. The space between the cells has a matrix ensuring a certain stability and provides cells with anchorage points. In the stem cell niche , cells with nutrients and oxygen are supplied.

Young Investigators Group “Stem Cell- Material Interactions ” led by Dr. Cornelia Lee- Thedieck composed of scientists from the Institute of Functional Interfaces GAME (IFG ), the Max Planck Institute for Intelligent Systems , Stuttgart, and the University of Tübingen. Artificially reproduces the main properties of natural bone marrow in the laboratory. With the aid of synthetic polymers , scientists created a porous structure simulating cancellous bone structure in the area of the bone marrow blood forming . Building blocks of proteins similar to anchor the cells are added to those in the matrix of the bone marrow. Scientists also insert other types of cells of the stem cell niche in the structure in order to ensure the exchange of substances .

Researchers then introduced hematopoietic stem cells isolated from cord blood in this artificial bone marrow. Subsequent breeding of the cells took several days . Analyzes with different methods revealed that the cells actually play in the newly developed artificial bone marrow . Compared with standard cell culture methods , more stem cells retain their specific properties in the artificial bone marrow.

The newly developed artificial bone marrow has significant properties of natural bone marrow , can now be used by scientists to study the interactions between the materials and the stem cells in the laboratory in detail . This will help you discover how the behavior of stem cells can be influenced and controlled by synthetic materials. This knowledge could contribute to producing an artificial stem cell niche for the specific reproduction of the mother and the treatment of leukemia cells ten or fifteen years from now .