FDA Cover’s Up Deaths in Drug Trials

FDA

FDA

Does the habitual use of antidepressants do more harm than good to many patients? Absolutely, says one expert in a new British Medical Journal report. Moreover, he says that the federal Food and Drug Administration might even be hiding the truth about antidepressant lethality.

In his portion of the report, Peter C. Gotzsche, a professor at the Nordic Cochrane Centre in Denmark, said that nearly all psychotropic drug use could be ended today without deleterious effects, adding that such “drugs are responsible for the deaths of more than half a million people aged 65 and older each year in the Western world.”

Gotzsche, author of the 2013 book Deadly Medicines and Organized Crime: How Big Pharma Has Corrupted Healthcare, further notes in the BMJ that “randomized trials that have been conducted do not properly evaluate the drugs’ effects.” He adds, “Almost all of them are biased because they included patients already taking another psychiatric drug.”

Hiding or fabricating data about harmful side effects

The FDA’s data is incomplete at best and intentionally skewed at worst, he insisted:

Under-reporting of deaths in industry funded trials is another major flaw. Based on some of the randomised trials that were included in a meta-analysis of 100,000 patients by the US Food and Drug Administration, I have estimated that there are likely to have been 15 times more suicides among people taking antidepressants than reported by the FDA – for example, there were 14 suicides in 9,956 patients in trials with fluoxetine and paroxetine, whereas the FDA had only five suicides in 52,960 patients, partly because the FDA only included events up to 24 hours after patients stopped taking the drug.

He said that he was most concerned about three classes of drugs: antipsychotics, benzodiazepines and antidepressants, saying they are responsible for 3,693 deaths a year in Denmark alone. When scaling up that figure in relation to the U.S. and European Union together, he estimated that 539,000 people die every year because of the medications.

“Given their lack of benefit, I estimate we could stop almost all psychotropic drugs without causing harm – by dropping all antidepressants, ADHD drugs, and dementia drugs (as the small effects are probably the result of unblinding bias) and using only a fraction of the antipsychotics and benzodiazepines we currently use,” Gotzsche wrote.

“This would lead to healthier and more long lived populations. Because psychotropic drugs are immensely harmful when used long-term, they should almost exclusively be used in acute situations and always with a firm plan for tapering off, which can be difficult for many patients,” he added.

Gotzsche’s views were disputed in the same BMJ piece by Allan Young, professor of mood disorders at King’s College London, and psychiatric patient John Crace.

“More than a fifth of all health-related disability is caused by mental ill health, studies suggest, and people with poor mental health often have poor physical health and poorer (long-term) outcomes in both aspects of health,” they wrote.

They also insisted that psychiatric drugs are “rigorously examined for efficacy and safety, before and after regulatory approval.”

 

Source:  globalresearch.ca

Magic mushrooms permanently changes personality

psilocybin mushroom

psilocybin mushroom

Psilocybe cubensis, commonly referred to as magic mushrooms have the potential to make a lasting change to one’s personality. This is a preliminary conclusion from a study conducted by Johns Hopkins researchers and published in the Journal of Psychopharmacology.

A single dose of ‘shrooms’ was enough to make a lasting impression on the personality in 30 of the 51 participants, or nearly 60%. Those who had a hallucinatory or mystical experience after consuming the mushrooms showed increased in the personality trait ‘openness’, which is closely related to creativity and curiosity. This increase was measured 2 months and even 14 months after the last session, which suggests long-term effects.

Study leader Roland Griffiths, a professor of psychiatry, finds this lasting impact on a personality trait remarkable: “Normally, if anything, openness tends to decrease as people get older.” Openness is one of five traits that were tested and the only one that changed during the study. Along with the other factors extroversion, neuroticism, agreeableness and conscientiousness, openness is one of the major personality traits that are known to be constant throughout one’s lifetime.

According to the researchers, this study is the first finding of a short-term means with which long-term personality changes can made. “There may be applications for this we can’t even imagine at this point,” says Griffiths. “It certainly deserves to be systematically studied.”

There is currently another study under way to determine whether or not psilocybin can help cancer patients deal with feelings of anxiety and depression.

 

Source:  azarius.pt

Sugar kills good cholesterol,

sugar

sugar

Scientists at the University of Warwick have discovered that ‘good’ cholesterol is turned ‘bad’ by a sugar-derived substance.

The substance, methylglyoxal – MG, was found to damage ‘good’ HDL cholesterol, which removes excess levels of bad cholesterol from the body.

Low levels of HDL, High Density Lipoprotein, are closely linked to heart disease, with increased levels of MG being common in the elderly and those with diabetes or kidney problems.

Supported by funding from the British Heart Foundation (BHF) and published in Nutrition and Diabetes, the researchers discovered that MG destabilises HDL and causes it to lose the properties which protect against heart disease.

HDL damaged by MG is rapidly cleared from the blood, reducing its HDL content, or remains in plasma having lost its beneficial function.

Lead researcher Dr Naila Rabbani, of the Warwick Medical School, says that: “MG damage to HDL is a new and likely important cause of low and dysfunctional HDL, and could count for up to a 10% risk of heart disease”.

There are currently no drugs that can reverse low levels of HDL, but the Warwick researchers argue that by discovering how MG damages HDL has provided new potential strategies for reducing MG levels.

Commenting on the research’s implications Dr Rabbani said:

“By understanding how MG damages HDL we can now focus on developing drugs that reduce the concentration of MG in the blood, but it not only be drugs that can help.

“We could now develop new food supplements that decrease MG by increasing the amount of a protein called glyoxalase 1, or Glo 1, which converts MG to harmless substances.

“This means that in future we have both new drugs and new foods that can help prevent and correct low HDL, all through the control of MG.”

A potentially damaging substance, MG is formed from glucose in the body. It is 40,000 times more reactive than glucose it damages arginine residue (amino acid) in HDL at functionally important site causing the particle to become unstable.

Glo1 converts MG to harmless substances and protects us. MG levels are normally kept low in the body to maintain good health but they slowly increase with ageing as Glo1 slowly becomes worn out and is only slowly replaced.

Dr Rabbani says: “We call abnormally high levels of MG ‘dicarbonyl stress’. This occurs in some diseases – particularly diabetes, kidney dialysis, heart disease and obesity. We need sufficient Glo1 to keep MG low and keep us in good health.”

Source:   eurekalert.org

High IQ and drug use

People that use drugs, are generally smarter than their counter parts:

High IQ linked to drug use

High IQ linked to drug use

The “Just Say No” generation was often told by parents and teachers that intelligent people didn’t use drugs.   Turns out, the adults may have been wrong.

A new British study finds children with high IQs are more likely to use drugs as adults than people who score low on IQ tests as children.  The data come from the 1970 British Cohort Study, which has been following thousands of people over decades.  The kids’ IQs were tested at the ages of 5, 10 and 16.  The study also asked about drug use and looked at education and other socioeconomic factors.  Then when participants turned 30, they were asked whether they had used drugs such as marijuana, cocaine and heroin in the past year.

Researchers discovered men with high childhood IQs were up to two times more likely to use illegal drugs than their lower-scoring counterparts.  Girls with high IQs were up to three times more likely to use drugs as adults.  A high IQ is defined as a score between 107 and 158.  An average IQ is 100. The study appears in the Journal of Epidemiology and Community Health.

The lead researcher says he isn’t surprised by the findings.  “Previous research found for the most part people with high IQs lead a healthy life, but that they are more likely to drink to excess as adults,” says James White a psychologist at Cardiff University in the United Kingdom.

It’s not clear why people with high childhood IQs are more likely to use illegal drugs.  “We suspect they may be more open to new experiences and are more sensation seeking,” says White.  In the paper, White and his co-author also mention other studies that find high IQ kids may use drugs because they are bored or to cope with being different.

That seems to ring true for one of my childhood classmates. Tracey Helton Mitchell was one of the smartest kids in my middle school. But, by the time she was in her early 20’s, Tracey was a heroin addict. I found out while flipping channels one sleepless night and stumbled upon the documentary “Black Tar Heroin.”

“I was confident in my abilities but there was a dissonance,” says Tracey, with whom I recently reconnected.  “No matter what I did, what I said, where I went, I was never comfortable with the shell I carried called myself.”

 

Source: CNN.Com

Drugs Create Super-Soldier

5 Drugs Used to Create a Super-Soldier:

 

5 Drugs Used to Create a Super-Soldier

5 Drugs Used to Create a Super-Soldier

Even though Super-Soldiers might sound like a bad narrative from a sci-fi film, they are more real than ever in a world obsessed with technological and biological advancement. Forget about crazy scientists in abandoned castlesthese drugs are real and they really work too. These drugs aren’t locked away in Area 51 type secret government bases either, a lot of these drugs are actually available right now for anyone to buy.

 

1. XBD173 : Anxiety Killer

Shell shock, post traumatic stress, different names but the same meaning. XBD173 is a drug that can not only eradicate anxiety and fear but it can do it instantly without any side effects or withdrawal symptoms. In total 1 in 8 soldiers, who’ve fought in the Iraq war, suffer from post traumatic stress disorder which is over 10% of the armed forces. Removing anxiety would create fearless and unstoppable soldiers who wouldn’t be affected by any of war’s brutalities or cruelties.

2. Provigil : No More Sleep

Imagine a soldier that didn’t need to sleep or rest half as much as a ‘normal’ soldier did? Completely possible with Provigil (AKA Modafinil) which was initially created to deal with narcolepsy, shift work sleep disorder and excessive daytime sleepiness. The drug radically improves work rate and alertness which means even with less sleep or rest, a soldier can work harder and more effectively.

3. D-IX : Nazi Cocaine

D-IX is a cocaine based drug originally created by the Nazis under Hitler’s evil reign. Criminologist and expert Wolf Kemper said “It was Hitler’s last secret weapon to win a war he had already lost long ago”. The drug was initially tested on prisoners at the Sachsenhausen concentration camp, they were given 20kg packs to carry and which marched with for 90km without rest.

4. Valproic Acid : Super Survivors

When a soldier suffers an injury that causes rapid blood loss, the body’s reaction is to go into shock which will sustain life for a short time however, if the body stays in shock for more than a short time, it can lead to organ failure, and death can soon follow. Valproic acid causes 87% of blood loss victims to survive (well in cows at least) which means that it could be possible to survive for prolonged hours after a bad injury.

5. Select Androgen Receptor Modulators : Instant Muscle Mass

Anabolic steroids are simply concentrated amounts of testosterone that rapidly build muscle mass but scientists have never been able to completely rid undesired side effects, until now. SARMs are a new and improved version of anabolic steroids that allows huge muscle growth without any side effects, whilst a potential super soldier wouldn’t be the size of the Incredible Hulk or nearly as green, this almost overnight treatment could turn a scrawny bunch of boys into a bulky troop of men.

Drugs companies profiting from Innovation crisis

Drugs companies putting profit ahead of medical discoveries, warn scientists:

 Drugs companies putting profit ahead of medical discoveries, warn scientists


Drugs companies putting profit ahead of medical discoveries, warn scientists

The multi-billion pound pharmaceutical industry has spent the last decade developing new drugs which have produced little benefit and caused considerable harm, experts say today. The claim that there is an “innovation crisis” in pharmaceuticals because of the difficulty and expense of discovering new drugs is a myth fostered by an industry whose chief focus is on marketing, they add. Counter to drug industry claims that the pipeline of new drugs is running dry, the number of new drugs being licensed each year has remained at between 15 and 25. But most involve minor tweaks to existing drugs, designed to grab a slice of an existing market rather than offering genuine therapeutic innovation. Independent reviews suggest that 85 to 90 per cent provide little benefit over existing treatments with some, such as Vioxx the painkiller and Avandia, the diabetes drug, causing serious side effects which led to their withdrawal, the latter’s in Europe. Writing in the British Medical Journal, Professor Donald Light from the University of Medicine of New Jersey and Joel Lexchin from York University in Toronto say the situation has remained the same for 50 years. The incentives for drug development are wrong and have skewed the behaviour of the industry. “This is the real innovation crisis: pharmaceutical research and development turns out mostly minor variations on existing drugs and most new drugs are not superior on clinical measures. [They] have also produced an epidemic of serious adverse reactions that have added to national healthcare costs,” they say. More is spent on marketing (25 per cent of revenues) than on discovering new molecules (1.3 per cent). Drug industry claims that the cost of bringing a new drug to market is £1bn and is unsustainable are exaggerated, they claim. Research and development costs did rise substantially between 1995 and 2010 by $34.2bn (£21.9bn), they concluded, but revenues increased six times faster – by $200.4bn. Companies avoid mentioning this “extraordinary revenue return”, they said, adding that up to 80 per cent of drug spending is used by the industry on promotion. The authors call for licensing authorities around the world to stop approving new drugs of little therapeutic value. They suggest large cash prizes should be awarded for genuinely new therapeutic agents in lieu of patent protection. The European Medicines Agency, which licenses drugs in the UK and Europe, keeps certain data about their safety and efficacy secret. Yet 29 per cent of new biological agents approved by the EMA received safety warnings within the first 10 years. In a second paper, researchers from the London School of Economics in the UK argue that drug manufacturers should be made to demonstrate that their products are superior to existing treatments before being granted a licence, rather than, as now, superior only to a placebo. “Changing the nature of regulation could encourage manufacturers to concentrate on the development of new drugs in therapeutic areas with few alternatives,” they say. “Supplementing regulation with scientific advice and guidance can steer manufacturer’s interest and efforts into key research priorities.” Stephen Whitehead, chief executive of the Association of the British Pharmaceutical Industry, said: “We strongly disagree with the claims made in these papers. Medical research has always rested on iterative and gradual innovation rather than breakthrough advances which are very rare. If it were not for the incremental improvements made in the treatment of HIV, the disease would still be terminal rather than a manageable condition.”

Coca-Cola: Phosphoric Acid

Dark History of Coca Cola:
Coca-Cola Cocaine

Coca-Cola Cocaine

In the beginning, Coke was brewed by Dr. John Stith Pemberton in 1886, since then Coca-Cola has grown into the world’s best-selling soda brand. In all its successes, Coca-Cola has been singled out on numerous occasions for its negative health effects and addictions. Coke was manufactured using Cocaine – This is where it got its name. The main consumers of Coca-Cola were overseas troops, fighting in the war. Cocaine, of course, helped to keep them on their toes, but many unaware soldiers came home addicted. When they returned home, they found it hard to find treatment for their addiction, because it was not as big a problem, as it is today, and not many solutions existed. The fact that the military complex was responsible for creating cocaine addiction in U. S. forces overseas is bad enough. When Coca-Cola was discovered to produce adverse health effects, to the point that they had to change their “secret formula,” they had to find a replacement for cocaine that would still produce a comparable “zing.” Enter caffeine, an “acceptable substitute.” What made it acceptable was not that it no longer contained an addicting substance or that there were no longer any side effects that inhibit a desireable level of health, but that the use of caffeine instead of cocaine allowed them to continue to peddle addictive substances, without the appearance of not caring one iota about the health of American citizens. Today a 12-ounce service of Coca-Cola contains 64 mg of caffeine, according to “Neuroscience for Kids,” the website of a University of Washington professor, Dr. Erik Chudler’s. Dr. Chudler writes that caffeine takes effect when absorbed into the bloodstream by the stomach and small intestine, which can happen between 15 and 60 minutes after consumption. While many people rely on caffeine to keep them alert, caffeine can be dangerous as it constricts arteries and veins and boosts heart rates. Coke knew, from both a scientific and ethical perspective that they are engaged in producing a product that has adverse health effects, but the love of money, made from its sales, overrides any health concerns. Major health concerns range from Sugar content, to Sperm count, even changing stomach acid levels.  Other than Cocaine being used in its first conception, the second most disgusting fact about this beverage is the phosphoric acid in Coca-Cola. It actually keeps you from vomiting! The sugar levels in Coke are enough to make you physically chuck, if it wasn’t masked by this dangerous chemical. Wow, you don’t see that on Coke’s website!  I compiled an interesting list of attributes Coca-Cola has, Enjoy your Coke.  I mean, Coca-Cola…
Coca-Cola Cocaine

Coca-Cola Cocaine

1. In many states (in the USA) the highway patrol carries two gallons of Coke in the truck to remove blood from the highway after a car accident. 2. You can put a T-bone steak in a bowl of coke and it will be chewed in days. 3. To clean a toilet: Pour a can of Coca-Cola into the toilet bowl and ……Let the real thing sit for one hour, then flush clean. The acid in Coke removes stains from vitreous china. 4. To remove rust spots from chrome car bumpers: Rub the bumper with a crumpled-up piece of Reynolds Wrap aluminum foil dipped in Coca-Cola. 5. Pour a can of Coca-Cola over the terminals to bubble away the corrosion. 6. To loosen a rusted bolt: Applying a cloth soaked in Coca-Cola to the rusted bolt for several minutes.

 7. To bake a moist ham: Empty a can of Coca-Cola into the baking pan, wrap the ham in aluminum foil, and bake. Thirty minutes before the ham is finished, Remove the foil, allowing the drippings to mix with the Coke for a sumptuous brown gravy.

 8. To remove grease from clothes: Empty a can of coke into a load of greasy clothes, add detergent, And run through a regular cycle. The Coca-Cola will help loosen grease stains. It will also clean road haze from your windshield.

 9. A active ingredient in Coke is phosphoric acid.  pH is approx. 2.8.

10. To carry Coca-Cola syrup (the concentrate) the commercial truck must use the Hazardous material placard reserved for Highly corrosive materials.

 11. Some distributors of Coke have been using it to clean the engines of their trucks for about 20 years!

12. Phosphoric acid does contribute to the taste of Coke.

It makes you wonder if Coca-Cola’s advertisement that includes a graphic swoosh line, is actually a cocaine line disguised as the real thing? Well the Coke in Coca-Cola use to be real at one point in time. So don’t think that throwing an eight ball of Coke in your Coca-Cola is acceptable!  You’re only supposed to do that with Champagne…

Coca-Cola cocaine
Coca-Cola cocaine