Microbes living in the skin of patients with primary immunodeficiencies:
Our skin is home to millions of microorganisms that cause disease, however, if our immune system influences these microbial communities to prevent the disease is unknown . In a study published online in Genome Research, researchers have explored the microbes that live on the skin of patients with primary immunodeficiency diseases of the skin eczema .
The human body contains many microbes , some of which are necessary for healthy bodily functions including digestion . Others, like some microbes living on our skin , may be pathogenic . Previous studies investigated how these microbes educate and shape the human immune system. It is not known , however , if the immune system influences the types of microbes that live on the skin and thus potentially prevent disease . ” In addition to questions about how microbes affect human host, there is interest in understanding how the human host affects the microbes that cause our skin to your home,” said Heidi Kong National Cancer Institute ( NCI ) and co -senior author of the study.
To study this, the authors recruited patients with reduced as a result of rare genetic defects immune function. Despite the diversity of the disease -causing mutations in patients, all patients share a skin condition eczema type . Scientists identified the microbes of the skin of patients by sequencing of microbial DNA from skin smears . Immunocompromised patients had types of bacteria and fungi in the skin that are not found in healthy individuals , suggesting the patients skin was more permissive for the growth of microbes . “Our findings suggest that the human body, including your immune system , limitations and potentially selects which bacteria and fungi can inhabit the skin,” Kong said.
Interestingly , the sites of the skin especially prone to the disease showed significant differences in microbial diversity , or the number of different types of microbes present in immundeficient patients. The skin on your elbow , for example, had fewer types of microbes that found in healthy individuals, while the skin behind the ear had more types of microbes. The authors suggest that an imbalance in the microbial diversity in a given site may contribute to the disease. Also, ” communities of bacteria and fungi on the skin of patients with primary immunodeficiency are more likely to change over time ,” said co -author Julie Segre of the National Institute of Human Genome Research (NHGRI ) .
Immunocompromised patients generally had similar microbial communities much more throughout the body, which are often different in healthy individuals . The authors suggest correcting diversity of microbes on the skin , not only the orientation pathogens, may help in the treatment of disease.
Although individuals in this study have rare genetic disorders , this research could have implications for patients with temporary problems in immune function , such as cancer patients and transplant recipients , and may inform the use of preventive antibiotics administered to these patients .